Wednesday brought a fresh batch of optimism from Wall Street, with several prominent analysts launching coverage on high-profile names—and they're all leaning bullish.

Leading the pack is Amazon.com, Inc. (AMZN), where Guggenheim analyst Simeon Siegel initiated coverage with a Buy rating and a $300 price target. That's a meaningful vote of confidence considering Amazon shares closed at $227.92 on Tuesday, suggesting Siegel sees plenty of room for the e-commerce and cloud computing giant to run.

Tech infrastructure also caught analyst attention. Keybanc analyst Jason Celino started coverage on Samsara Inc. (IOT) with an Overweight rating and a $55 price target. Samsara, which provides IoT solutions for physical operations, closed at $43.79 on Tuesday—putting Celino's target about 25% above current levels.

The consumer space saw another bullish call from Guggenheim's Siegel, who initiated coverage on NIKE, Inc. (NKE) with a Buy rating and a $77 price target. Nike shares ended Tuesday at $63.33, so Siegel is betting the athletic apparel titan has more gains ahead despite recent challenges in the retail environment.

Healthcare got some love too. Deutsche Bank analyst David Hoang launched coverage on Apogee Therapeutics, Inc. (APGE) with a Buy rating and a $103 price target. The biotech company closed at $74.74 on Tuesday, giving Hoang's target some substantial upside potential.

Rounding out Wednesday's bullish initiations, Freedom Capital Markets analyst David Silver started coverage on ABM Industries Incorporated (ABM) with a Buy rating and a $54 price target. The facilities services company traded at $44.66 on Tuesday, putting it well below Silver's optimistic forecast.

All five initiations share one thing in common: analysts see meaningful upside from current trading levels. Whether it's Amazon's cloud dominance, Nike's brand power, or the growth trajectories of smaller players like Samsara and Apogee, Wall Street is putting chips on the table and signaling confidence in these names.