Wednesday morning brought some rough trading for several stocks even before the opening bell, with U.S. stock futures showing modest weakness. The Nasdaq 100 futures were down around 0.1% as investors digested overnight developments.

The biggest pre-market decliner was SeaStar Medical Holding Corp (ICU), which saw shares crater following news of a 1-for-10 reverse stock split. The medical device company's stock fell 9.5% to $0.21, a move that reflects investor skepticism about reverse splits—often seen as a last-ditch effort to maintain exchange listing requirements.

Other notable movers in the red included:

Coincheck Group NV (CNCK) dropped 11% to $2.28, leading decliners in the crypto-adjacent space.

Ascent Solar Technologies, Inc. (ASTI) pulled back 7.6% to $4.67, giving back some of Tuesday's impressive 30% gain. Classic case of profit-taking after a momentum run.

Jet.AI Inc (JTAI) slid another 5.3% to $0.82, extending Tuesday's brutal 28% decline. The continued selloff came despite the company announcing a planned joint venture with Choo Choo Express to develop a 50-megawatt data center campus in Nevada. Apparently, the data center news wasn't enough to stop the bleeding.

Lifestance Health Group Inc (LFST) declined 3.7% to $6.80 in early action.

Precision Drilling Corp (PDS) fell 3.3% to $66.96 as energy sector names showed weakness.

Vasta Platform Ltd (VSTA) rounded out the list of decliners, down 3.1% to $4.80 in pre-market trading.