Sometimes good news and bad news arrive at the same time, and investors have to decide which matters more. For BriaCell Therapeutics Corp. (BCTX), Wednesday delivered exactly that scenario. The stock cratered more than 50% in premarket trading, hitting a fresh 52-week low at $5.05, despite announcing some genuinely encouraging cancer trial results just a day earlier.
The culprit? A $30 million capital raise that hit after Tuesday's close. BriaCell, a small-cap cancer-focused biotech with a market capitalization of roughly $20.57 million, priced an offering of 5.37 million units at $5.59 each. Each unit includes one common share (or a pre-funded warrant as an alternative) plus one warrant with an exercise price of $6.93 per share. Translation: existing shareholders are getting diluted, and the market isn't thrilled about it.
The Good News That Got Buried
Here's what should have been the headline: BriaCell reported that a patient with metastatic breast cancer achieved durable and sustained complete resolution of a lung metastasis. We're talking about a 78-year-old woman with advanced disease who had already failed multiple prior treatments—not exactly the easiest patient population to show results in.
After receiving just four doses of Bria-OTS as a single-agent therapy, this patient saw 100% resolution of a lung metastasis. The complete response was first spotted at two months, then confirmed again at four months, six months, and now at 11 months. The patient went through 17 cycles of treatment, completed the full 12-month study, and continues in survival follow-up.
Bria-OTS is an off-the-shelf personalized immunotherapy derived from BriaCell's lead candidate Bria-IMT. It's currently being evaluated in a Phase 1/2a study for metastatic recurrent breast cancer, covering both monotherapy dose escalation and checkpoint inhibitor combination dose expansion cohorts. This particular patient was hormone receptor-positive and HER2-negative.